Study of DNA Interaction and Cytotoxicity Activity of Oxidovanadium(V) Complexes with ONO Donor Schiff Base Ligands

Two new oxidovanadium(V) complexes, (HNEt3)[VVO2L] (1) and [(VVOL)2?-O] (2), have been synthesized using a tridentate Schiff base ligand H2L [where = 4-((E)-(2-hydroxy-5-nitrophenylimino)methyl)benzene-1,3-diol] VO(acac)2 as starting metal precursor. The corresponding complexes are characterized by physicochemical (elemental analysis), spectroscopic (FT-IR, UV–Vis, NMR), spectrometric (ESI–MS) methods. X-ray crystallographic analysis indicates the anion in salt 1 features distorted square-pyramidal geometry for vanadium(V) center defined imine-N, two phenoxide-O, oxido-O atoms. interaction of compounds with CT–DNA was studied through UV–Vis absorption titration circular dichroism results indicated that showed enhanced binding affinity towards DNA compared to molecule. Finally, vitro cytotoxicity studies H2L, 1, 2 were evaluated against colon cancer (HT-29) mouse embryonic fibroblast (NIH-3T3) cell lines MTT assay. demonstrated manifested cytotoxic potential comparable clinically referred drugs caused death apoptosis.